Some causes of elevated alkaline phosphatase include
Paget disease, healing fractures, acromegaly, osteogenic sarcoma, liver or bone
metastases, leukemia, myelofibrosis, rickets, osteomalacia, hypervitaminosis D ,
cholestasis of pregnancy, biliary obstruction, hyperthyroidism, infiltrative
liver diseases (eg, sarcoid, TB, amyloidosis, abscess), cirrhosis, and myeloma.
Low levels may be found in hypophosphatasia, and less commonly in hypothyroidism