Reference Values During Pregnancy

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Cancer Antigen (CA) 125 (serum)

   Units Nonpregnant Adult First Trimester Second Trimester Third Trimester
U/ml < 35 0 -  51.5 0 -  30.8 0 -  56.3

A normal level of CA-125 does not exclude tumor.

Some causes of increased CA-125 include nonmucinous epithelial ovarian carcinoma, Fallopian tumors, cervical adenocarcinoma, endometrial carcinoma, trophoblastic tumor, carcinomas of the GI tract and lung, ascites, renal failure, cirrhosis, pancreatitis,  benign gastrointestinal diseases, adenomyosis, uterine fibroids, and pelvic inflammatory disease.


1. .Touitou Y , et. al. Tumour marker antigens during menses and pregnancy. Br J Cancer. 1989;60:419-20. PMID:2789952
2. Tan MCB, Goedegebuure PS, Eberlein, TJ : Tumor Biology and Tumor Markers In: Townsend CM Jr, ed. Sabiston Textbook of surgery 18th ed WB Saunders, Philadelphia, 2007 . p762

3. Wallach, J. Interpretation of Diagnostic Tests, Eighth ed. Lippincott Williams & Wilkins, 2007

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