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Reference Values During Pregnancy


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Complement, C4  (serum)

   Units Nonpregnant Adult First Trimester Second Trimester Third Trimester
mg/dL 16 - 47 9 - 45 10 - 42 17 - 37
g/L 0.16 - 0.47 0.09 - 0.45 0.10 - 0.42 0.17 - 0.37

Some causes of decreased C4 include systemic lupus erythematosus, lupus nephritis, hereditary angioneurotic edema, hereditary C4 deficiency ,glomerulonephritis, and infancy.


References:

1. Lockitch G. Handbook of Diagnostic Biochemistry and Hematology in Normal Pregnancy. Boca Raton:CRC, 1993.
2. Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009 Dec;114(6):1326-31. PMID:19935037
3. Wallach, J. Interpretation of Diagnostic Tests, Eighth ed. Lippincott Williams & Wilkins, 2007
4.Appendix. Published Reference Interval During Pregnancy.In: Gronowski AM ed. Handbook of Clinical Laboratory Testing During Pregnancy .  Totowa , NJ: Humana Press , 2004:423- 437.

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