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Reference Values During Pregnancy


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Thyroid Stimulating Hormone (TSH)

   Units Nonpregnant Adult First Trimester Second Trimester Third Trimester

µIU/mL or mIU/L

0.34 - 4.25 0.6 - 3.4 0.37 - 3.6 0.38 - 4.04

mU/L

0.34 - 4.25 0.6 - 3.4 0.37 - 3.6 0.38 - 4.04

Some causes of elevated TSH include primary hypothyroidism (Hashimotos thryroiditis), TSH secreting pituitary tumor, thyroid hormone resistance, insufficient T4 therapy for hypothyroidism, adrenal insufficiency, iodine, lithium, and antithyroid drugs.

Some causes of low TSH levels include, hyperthyroidism (Graves' disease),  stimulation of the TSH receptor by hCG (first trimester of pregnancy, hyperemesis gravidarum, molar pregnancy/choriocarcinoma), exogenous thyroid hormone, thyroiditis, an autonomous thyroid nodule, dopamine, glucocorticoids, secondary hypothyroidism.


References:

1. Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009 Dec;114(6):1326-31. PMID:19935037
2. Brent GA.Maternal thyroid function: interpretation of thyroid function tests in pregnancy.Clin Obstet Gynecol. 1997 Mar;40(1):3-15.
PMID: 9103946

 

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