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Pediatric AIDS Clinical Trials Group (PACTG)
076 Zidovudine (ZDV) Regimen 
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(PACTG) 076 Zidovudine (ZDV) Regimen
|Time of ZDV administration ||
Oral administration of 100 mg ZDV five times daily, initiated at 14-34 weeks' gestation and continued throughout the pregnancy. |
During labor,intravenous administration of ZDV in a 1-hour initial dose of 2 mg/kg body weight,followed by a continuous infusion of 1 mg/kg body weight/hour until delivery. |
Oral administration of ZDV to the newborn (ZDV syrup at 2 mg/kg body weight/dose every 6 hours) for the first 6 weeks of life,beginning at 8-12 hours after birth. (Note: intravenous dosage for infants who can not tolerate oral intake is
1.5 mg/kg body weight intravenously every 6 hours.)|
ACOG Opinion on Prophylactic Scheduled Cesarean .
- Optimally, IV ZDV should be instituted at least 3 hours prior to surgery.
- Parturients with viral loads greater than 1000 copies/mL should be counseled regarding the potential benefit of scheduled cesarean delivery at 38 weeks.
- Data are insufficient to demonstrate a benefit for neonates of women with viral loads less than 1000 copies/mL and show no reduction in the rate of transmission if cesarean delivery is performed after the onset of labor or rupture of membranes.
- The patient's autonomy should be respected in making the final decision regarding route of delivery.
- Prophylactic antibiotics should be considered because of the increased infectious morbidity.
- Amniocentesis, application of a fetal scalp electrode, and other invasive procedures should be avoided whenever possible.
1. Public Health Service Task Force Recommendations for the Use of Antiretroviral Drugs in Pregnant Women Infected with HIV-1 for Maternal Health and for Reducing Perinatal HIV-1 Transmission in the United States
MMWR January 30, 1998 / 47(RR-2);1-30
2. ACOG Committee Opinion, Number 234, May 2000:
Scheduled Cesarean Delivery and the Prevention of Vertical Transmission of HIV Infection, American College of Obstetricians and Gynecologists. Washington, D.C.
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